Study on the recommendation of anti-oxidant nutrients in type 2 DM patients

• Main Authors: Wu, Jau-Shian, 吳昭嫺
• Other Authors: Chan, Kung-Chi
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/27252380481499070446

碩士 === 靜宜大學 === 食品營養學系 === 100 === Hyperglycemia-induced oxidative damages contribute to the development of vascular complications, and macrovascular complications are the major cause of death in end-stage type 2 diabetic patients. The purpose of this study was to investigate the anti-oxidative nutrients consumption and we also intent to set up a preliminary recommendation of anti-oxidative nutrients for type 2 diabetic patients. Intake of anti-oxidative nutrients, including vitamin C, vitamin E, β-carotene and zinc, was analyzed by using the data bank of a national-based cross-sectional survey, the Nutrition and Health Survey in Taiwan (NAHSIT) 2005~2008. The 24-hours dietary record data from diagnosed diabetic patients and patients treated with hypoglycemic agents was cited in this study. In addition, several categories of references, in relation to diabetic patients receiving antioxidant supplements, were collected and Meta-analyzed in this study. The results showed that the average vitamin C intake of diabetic patients from NAHSIT (2005~2008) was 119.6 mg, which was higher than the DRIs for healthy adults. However, only 55.3% of subjects, there vitamin C intake was above the Taiwanese DRIs for healthy adults of 100 mg/day. The average vitamin E and zinc intake were 6.4 mg α-TE and 8.8 mg, respectively, which were lower than the DRIs for healthy adults. Those intakes of vitamin E and zinc above the DRIs were only 16.6% and 12.5%, respectively. In addition, the intake of vitamin C and vitamin E above the DRIs of diabetic patients without complications were 59.7% and 18.7%, respectively. These values were higher than those patients with complications having values of 51.3% and 14.7%, respectively. These results indicate that the anti-oxidative nutrients intake of diabetic patients in Taiwan are insufficient, which may decrease their anti-oxidative capacity and hence increase the risk to develop vascular complications. Moreover, according to our literature survey, increased intakes of anti-oxidants supplements exert beneficial effects for diabetic patients to prevent the development of micro- and macro-vascular complications. We therefore suggest that daily consumption of vitamin C doses at least 5 times of DRIs, vitamin E doses at least 5.6 times of DRIs, zinc doses at least 2-2.5 times of DRIs, or supplementing additional doses of β-carotene at 60 mg/day or selenium at 960 μg/day, may decrease thrombogenic risks in type 2 diabetic patients.