Preparation and In Vitro Evaluation of Drug Loaded Tissue Conditioners

• Main Authors: Chi-sheng Lo, 羅濟生
• Other Authors: Chen-yu Kao
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/ud7894

碩士 === 國立臺灣科技大學 === 醫學工程研究所 === 100 === In this study, a drug incorporated tissue conditioner is developed for the delivery of Flurbiprofen (FB),an anti-inflammatory drug, and itraconazole (ITZ), an anti-fungal drug in the oral environment. This drug incorporated tissue conditioner provides two unique properties for treating denture-related stomatitis: (1) the tissue conditioner is used to reduce the damage of unfit denture by cushioning the hard denture base against the healing extraction sites. (2) the tissue conditioner is used as a depot for both anti-inflammatory drugs and anti-fungal drugs. In our study, the drug incorporated tissue conditioner showed a dual-phase release kinetics. The hydrophilic anti-inflammatory drug was rapidly released (96% of FB was released in a 7 day period) and the hydrophobic anti-fungal drug was released at a relatively slow pattern (30% of ITZ was released within 7 days, and 33% released within 14 days). We expected this drug incorporated tissue conditioner will create a synergistic effect of physical/chemical therapy for treating denture related stomatitis.