Time-domain and Frequency-domain Analysis on Skin-Surface Laser Doppler Signals in Diabetes Patients

• Main Authors: Guan-Shain Wu, 吳冠賢
• Other Authors: Shin Shiu
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/965xw9

碩士 === 國立臺灣科技大學 === 醫學工程研究所 === 100 === Diabetes is the fifth leading cause of death in Taiwan, mainly because the glycemia of diabetic always maintained with high level. This phenomenon not only raises the viscosity of blood flow but also make the interchange efficiency of blood substance getting lower, which may further result in many vascular lesions. In this study, we aim to understand the physiological changes of subject during the Oral Glucose Tolerance Test (OGTT). We apply the non-invasive instrument to measure the blood signal of subject’ extremities and analyze the signal with the following two forms: frequency-domain and time-domain. We divided the subjects into three groups, the subject with Diabetes is called A group, the subject with high glycemia is called B group, the subject with normal glycemia is called C group. From the result, we noted that the endothelial function, neurogenic activity and myogenic activity of A group can be injured. In addition, the vascular occlusion and blood flow resistance of A group can be worse than B group and C group. The result also could explain the reaction of short-term glycemia fluctuation. According to the present finding we can detect the changes of blood flow and vascular characteristics before getting Diabetes. In conclusion, we understand the hyperglycemia has significant damage on microcirculatory blood flow supply, and we also could get more information during pre-Diabetes stage.