| Summary: | 碩士 === 國立臺灣科技大學 === 化學工程系 === 100 === Part I
This research claims a facile syntheses route for I-II-III-VI heterostructures Cu2S-ZnS, Cu2S-CuInS, and Cu2S-CuInZnS in a noncoordinating solvent. We exploit seed-mediated synthesis as a basis of crystal growth. The Cu2S seed and ZnS anisotropic nanorod are prepared by thermal decomposition and hot-injection respectively. By using 1-dodecanethiol as both the reactant for the sulfur source and the capping ligands, with copper acetate as the copper source, we synthesized Cu2S and Cu2S-CuInS seeds in the absence and presence of indium acetate, respectively. In the section of the parameter adjustment, we control the heterostructures aspect ratios by changing different reaction temperature, injection volume, and various annealing time, then successful control of the heterostructures length in a range of 20 nm to 200 nm. In summary, this one-pot two-step approach can be successfully, because both seeds and precursors can be grown controllably in the same reaction vessel, and without intermediate seed purification, yielding easy handling, large-scale production capability, and high synthetic reproducibility. In the future, we hope that these nanoheterostructures will be applied to optoelectronic and photovoltaic.
Part II
This research successfully proposed a reliable method for preparing multifunctional CuInS2 nanoparticle, which be able to applied in fluorescent imaging, magnetic resonance imaging, and tumor-specific targeting. This study is divided into three parts: (1) amphiphilic copolymer, PMAO, was wrapped on the surface of CuInS2 quantum dot to create a large number of carboxyl group, thus not only conferring the QDs water dispersible but also provides useful reactive groups for further functionalization; (2) to integrate the MRI capability of our quantum dot. paramagnetic gadolinium chelates (Gd-DTPA) was further conjugated with carboxy group on the surface of the CuInS2 quantum dots, which is denoted as Gd-CuInS2 quantum dots, by using straightforward EDC/NHS catalyzed coupling reaction. (3) to demonstrate the targeting capability of these newly synthesized quantum dots, we have used folate-receptor targeting by utilizing folic acid to conjugated with the Gd-CuInS2 quantum dots, which is denoted as FA-Gd-CuInS2. Folic acid, a high affinity ligand to floate receptors is efficiently internalized into the cell through the receptor mediated endocytosis even when conjugated with a wide variety of molecules. The results reveal that the FA-Gd-CuInS2 quantum dots show highly effective dual-modality imaging probes for specific cancer diagnosis.
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