Novel biodegradable elastomers from waterborne processes for biomedical applications

• Main Authors: Chun-Yi Lu, 呂俊逸
• Other Authors: Shan-hui Hsu
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/34334207980509179711

碩士 === 國立臺灣大學 === 高分子科學與工程學研究所 === 100 === Waterborne biodegradable polyurethane (WBDPU) ionomers were synthesized in this study. The soft segments employed the combination of two macrodiols, which were polycaprolactone diol (PCL diol) and a choice from polyethylene butylene adipate diol (PEBA diol) or polylactic acid diol (PLA diol, L-form or D,L-form). The mechanical properties, microphase separation, and degradation rate could be modulated by the ratios between PCL diol and the other macrodiol. The degradation rate of WBDPU was positively correlated with the type and ratio of macrodiols both in vitro and in vivo. WBDPU had better endothelial cell (EC) attachment and proliferation with lower immune response than Pellethane. The gene expression of endothelial nitric oxicde synthase was up-regulated by WBDPU. WBPDU showed lower platelet adhesion and activation than PLA and Pellethane. WBDPU implanted in subcutaneous rats showed lower capsule thickness than PLA, indicating the smaller foreign body reaction. WBDPU could also be conveniently processed into electrospun fibers as well as two-dimensional (2D) porous membranes with adequate EC attachment and three-dimensional (3D) scaffolds with proper mesenchymal stem cell seeding efficiency. The WBDPU synthesized in this study were novel biomedical elastomers that may find applications in the repair and regeneration of cardiovascular and other soft tissues.