Using Finite-Difference Time-Domain Method to Study Light Scattering Difference between Normal and Cancerous cells

• Main Authors: Chih-Chiang Chang, 張智強
• Other Authors: 宋孔彬
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/67849857605137887748

碩士 === 國立臺灣大學 === 生醫電子與資訊學研究所 === 100 === Tumor now is still a troublesome disease for human. Since light scattering is very sensitive to the cell structure and refractive index, if I could build up the tool to simulate the light scattering phenomenon of different kind of cells such as cancer and normal,and it may be a potential database for clinical diagnosis for non-invasive epithelium cancer in the future. In my thesis, I apply finite difference time domain (FDTD) method to build up my simulation tool. The FDTD method is based on Maxwell Equations in Electromagnetics. Furthermore, It is very flexible and reliable methods that you can modify many parameters such as structure or refractive index of scattering objects, and even the waveform incident wave. We can use this method to simulate the light scattering of cancerous cell and normal cell and try to find there feature by FDTD method. Last but not least, I also make use of the data obtained from the Tomography Phase Microscopy, which could provide the precise three dimensional refractive index composition of cell and even the morphology of cell. This is the kind of breakthrough that we can simulate the light scattering of cell using the exact experimental data but not an refractive index average of the cell which are usually used by previous research.