Iron Trichloride-Promoted Construction of Spiro[4.6]undecan-8-ones
碩士 === 國立臺灣師範大學 === 化學系 === 100 === Construction of spiro[4.6]undecan-8-ones via iron(III) chloride-promoted tandem ring expansion/cyclization/chlorination of arylalkynyl-tethered bicyclo[4.1.0]heptan-2-ones was demonstrated. Treatment of arylalkynyl-tethered bicyclo[4.1.0]heptan-2-ones with 1.5...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2011
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| Online Access: | http://ndltd.ncl.edu.tw/handle/99519317633751957257 |
| Summary: | 碩士 === 國立臺灣師範大學 === 化學系 === 100 === Construction of spiro[4.6]undecan-8-ones via iron(III) chloride-promoted tandem ring expansion/cyclization/chlorination of arylalkynyl-tethered bicyclo[4.1.0]heptan-2-ones was demonstrated.
Treatment of arylalkynyl-tethered bicyclo[4.1.0]heptan-2-ones with 1.5 equivalents of iron(III) chloride in 1,2-dibromoethane at 50 ℃ afforded spiro[4.6]undecan-8-ones in 24-62 % yield. Structure elucidation of the (E)-form products was achieved by X-ray crystallography.
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