Determination of Six Halogen Amphetamines Designer Drugs by Capillary Electrophoresis Ultraviolet Absorbance/Laser-Induced Fluorescence and Paper Spray

• Main Authors: Hsun Lee, 李珣
• Other Authors: Cheng-Huang Lin
• Format: Others
• Language: zh-TW
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/80027521830074171224

碩士 === 國立臺灣師範大學 === 化學系 === 100 === Substitutions to the amphetamine molecule give rise to a group of derivatives, and, as a result, a number of illegal, amphetamine-like drugs are produced in underground labs for sale on the street. In this study, we selected o-, m-, p-chloro- and o-, m-, p-fluoro-amphetamines as model compounds. Optimal conditions for the separation and detection of a mixture of six halogen amphetamines are described, by the use of capillary electrophoresis ultraviolet absorbance in conjunction with online sample concentration techniques. And the six designer drugs in a human saliva are also separated by use of the capillary electrophoresis laser-induced fluorescence. The results obtained by the microwave assisted fluorescent labeling method was compared and discussed to regular analytical method. In Taiwan, p-chloroamphetamine (PCA) was permanently placed in Schedule III in 2011. A method for the rapid screening and determination of PCA in saliva by a novel nib-assisted paper spray-mass spectrometry (NAPS-MS) procedure is described. The detection limits and precision of PCA by use four of the paper spray materials are discussed and the complete data are reported herein. Under optimized conditions, the limit of detections (LODs) for amphetamine derivatives were determined to 0.1 µg/mL by the NAPS-MS method.