| Summary: | 碩士 === 國立清華大學 === 電機工程學系 === 100 === The central nervous system (CNS) is the most important system to most of multicellular animals. Once the CNS gets damaged, animals had better regenerate it back. Regeneration is one of the most interesting biological phenomena but its molecular and cellular mechanisms are still unclear. Danio rerio is a good model to investigate these mechanisms since it can regenerate many types of CNS tissues, including cerebellum, while we humans cannot. In this study, we applied several frequently-adopted methods such as time series analysis, pathway enrichment analysis, and promoter analysis to the temporal microarray profile of zebrafish after traumatic brain injury, as well as constructed a wound healing-related protein-protein interaction (PPI) network of zebrafish with the dynamic cellular model and system identification approaches. According to these analyses, many significant pathways and crucial transcription factors in wound healing process were identified. From these important results, we can gain more insights into the specific molecular mechanisms in CNS regeneration process and make human CNS regeneration more feasible in the future.
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