A model of synaptic plasticity at multiple temporal scales for the neuronal plasticity induced by repetitive transcranial magnetic stimulations

• Main Authors: Chen, Li-Rui, 陳李睿
• Other Authors: Lo, Chung-Chuan
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/13408882146721681565

碩士 === 國立清華大學 === 系統神經科學研究所 === 100 === Transcranial magnetic simulations (TMS) is an effective tool for studying pathophysiology of dystonia as well as various other movement or cognitive functions of the brain. In previous studies, synaptic plasticity induced by TMS might be the key of recovering the abnormality in motor cortex. To study how TMS induces complex plasticity, we built computational models for pre-synaptic short-term plasticity and post-synaptic calcium dependent plasticity. With integration of these different time scale plasticity, Our model have successfully reproduced neural plasticity induced by a number of repetitive TMS protocols and Theta Burst stimulation (TBS).We will be able to provide insights into neuronal mechanisms underlying the effectiveness of TMS. Our result indicates that pre-synaptic short-term plasticity affects post-synaptic long-term plasticity by changing calcium concentration.