| Summary: | 碩士 === 國立臺北護理健康大學 === 護理研究所 === 100 === The purpose of this study was to investigate the relationships of chemotherarpy induced neuropathic pain, activies of daily lives, mood and quality of life among patients with colorectal cancer in Taiwan. A convenience sample was used in this cross-sectional study. The data was collected by self-administrated questionnaires. The instruments included Neuropathic Pain Symptom Inventory (NPSI)、Screening of Activity Limitation and Safety Aweareness Scale (SALSA scale）、Profile of Mood States short form (POMS SF）and Functional Assessment Cancer Therapy-Colorectal instruments version 4 (FACT-C version 4) as well as self-constructed items. A total of 106 questionnaires were distributed.
The results revealed majority of the participants were male (53.8%) and married (77.4%). The average age was 56.92(SD=11.35). The level of education and occupation in most participants were senior high school (29.2%) and housekeeper (20.8%). The stage of cancer in most participants was stage III (60.4%) and IV (34.0%). There was history of chronic disease in the majority of the participants (63.2%) as well as history of post radical resection following by oxaliplatin/ 5-Fu-based chemotherapy (FOLFOX) (95.3%). On the incidence of chemotherapy induced neuropathic pain, majority of the participants is slight (93.4%). The severity of chemotherapy induced neuropathic pain from high to low was paraesthesia, intermittently neuropathic pain, induced neuropathic pain, and spontaneously neuropathic pain, subsequently. On the domain of activities of daily lives, minority of the participants is slight restriction (11.3%). The restrictive severity of activities of daily lives from high to low was self-care, work of hand, dexterity of hands and mobility of feet, subsequently. The score of each domain in mood from high to low was vigor-activity, confusion-bewilder, fatigue-inevtia, tension-anxiety, depression- dejection, and anger-hostility, subsequently. The results indicated that there were a low positive correlation between paraesthesia and dexterity of hands (r＝.196, p<.05), a medium positive correlation between neuropathic pain and mood (r＝.492, p<.001), a medium negative correlation between spontaneously neuropathic pain and quality of life (r＝-.254, p<.01). In additional, a medium positive correlation between activities of daily lives and mood (r＝.388, p<.01), a medium negative correlation between activities of daily lives and quality of life (r＝-.328, p<.01) and a high negative correlation between mood and quality of life were reported (r＝-.615, p<.001). Results from the hierarchical multiple regression analysis detected that stage, accumulative dose of chemotherapy, spontaneously neuropathic pain, and activies of daily lives were determinants in quality of life before mood was included. They can explained 45.2% of the variance on quality of life. Furthermore, the mediating effects of perceived mood on quality of life was analyzed by ordinary least square multiple regression analysis. The result showed 42.51% variance of spontaneously neuropathic pain on quality of life and 43.17% variance of activies of daily lives on quality of life could explained by perceived mood.
The result from the current study may provide new insight into status and relationships of chemotherapy induced neuropathic pain, activies of daily lives, mood and quality of life among the patients with colorectal cancer. Strategies which aim to improve the quality of life among patients with colorectal cancer may be developed through the enhancement of nursing evaluation of chemotherapy induced neuropathic pain, activities of daily lives and mood, as well as strengthening management of care guideline.
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