Associated Factors of Tumor Size in Colorectal Cancer and Depth of Bowel Wall Invasion

• Main Authors: Li-fang Chiu, 邱麗芳
• Other Authors: Chieh-hsiang Lu
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/06765206831758819180

碩士 === 南華大學 === 自然醫學研究所 === 100 === 　　Background: It is estimated by the World Health Organization that worldwide, in 2008, 1.23 million cases of colorectal cancer were clinically diagnosed, and that it killed over 600 thousand people. Though preoperative staging of colorectal cancer is important, making the final decision has shown very complicated. This might be resulted in an inapropriated expectation of patients to the course of the disease. Furthermore, the discrepancy of preoperative and postoperative stagings also may make complaints from doctors and patients. 　 　　Purpose: The goal of this study was to investigate the relationships between tumor size in colorectal cancer and depth of bowel wall invasion, and the associations between the stage of cancer and 5-year survival rate refers to the percentage of patients. 　 　　Methods: Researchers used secondary data analysis to assess the associated factors of tumor size, stage of cancer, and 5-year survival rate of coloreatal cancer individuals provided from the Cancer Registory database established by a regional teaching hospital in Chiayi city from 2004 to 2008. Descriptive statitstics and chi-square test were used to evaluate the independent factors of tumor size in colorectal cancer associated with and the depth of bowel wall invasion and 5-year survival rate. 　 　　Results: A total of 695 cases were enrolled in this study. Results showed that the tumor size was not correlated with gender and age, while it was significantly associated with the depth of bowel wall invasion (P<0.001). In turn of tumor in right colon, left colon and rectum were further subtyped by their median sizes (60 mm, 42.5 mm, and 45 mm, respectively) to analyze the associated factors among median tumor size, bowel wall invasion, and stage of tumor. Results showed that the median tumor size in left colon still significanty associated with the pathological stage. The rectum also significanty associated with the pericolic lymph node, the distances of metastasis, and stage of tumor (P=0.005, 0.001, and <0.001, respectively).The median tumor sizes of left colon and rectum were significanty associated with the 5-year survival rate (P=0.036 and 0.012, respectively. 　 　　Conclusions: In conclusion, the tumor size was significantly associated with the depth of bowel wall invasion. The health care professionals should pay more attention to pericolic lymph node and the distant metastasis, especially the rectal cancer size is over 45mm.