Synthesis of D-Mannosamine and Its Derivatives

• Main Authors: Pu-Ling Hu, 胡圃苓
• Other Authors: Cheng-Chung Wang
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/56326855706540674459

碩士 === 國立中央大學 === 化學研究所 === 100 === Abstract Sialic acids play important roles in many biological processes including cell-cell interaction, bacterial and viral infection as well as tumor metastasis. Developing a strategy to observe sialic acid distribution on cell surfaces can assist our understanding in the relationship between sialic acids and diseases. Metabolic oligosaccharide engineering (MOE) has been employed to express modified sialic acid derivatives on cell surfaces via glycan synthesis pathways in cells using mannosamine derivatives as the starting materials. In this thesis, due to the high costs of mannosamine, we aim to develop an efficient and novel method for the synthesis of mannosamine derivative 7a.