Studies of alpha-nucleophilic conjugate addition reaction
碩士 === 國立交通大學 === 應用化學系碩博士班 === 100 === In this thesis, we used phosphines as nucleophilic reagents to attack alpha carbon of polyyne, followed by cyclization, to give gamma-lactones. We obtained gamma-lactone bearing alpha-ylide in one pot and characterized them by NMR, IR, MS and X-ray diffraction...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2012
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| Online Access: | http://ndltd.ncl.edu.tw/handle/36141264194536562703 |
| Summary: | 碩士 === 國立交通大學 === 應用化學系碩博士班 === 100 === In this thesis, we used phosphines as nucleophilic reagents to attack alpha carbon of polyyne, followed by cyclization, to give gamma-lactones. We obtained gamma-lactone bearing alpha-ylide in one pot and characterized them by NMR, IR, MS and X-ray diffraction analyses. To optimize and discuss the substituent effects, we study reactions under different conditions and replace different reactants in this multi-component reactions. These readily available structures may be adventageous to the total synthesis of molecules having lactones moiety.
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