| Summary: | 碩士 === 國立交通大學 === 電控工程研究所 === 100 === This research utilizes Micro-Electro-Mechanical-System(MEMS) technology process to develop bio-electrode to measure Sprague Dawley(SD) rat’s Electrocorticography(ECoG) signal. The electrical signal in rat’s brain is evoked by auditory stimulation and can be detected with the new developed bio-electrode sensor. And then the back-end system will record signals from eighteen positions. We choose two signals as the ground signal and reference signal, respectively. After one hundred times average, we can analyze the relationship between temporal resolution and spatial resolution of sixteen positions of brain.
The Bio-electrode is fabricated with two parylene layers (10um, 1um) to cover the platinum metal wires. Oxygen Plasma is used to etch electrode’s size and define the shape of Bio-electrode. After process, we can stably batch production of electrode device. In order to implant into rat’s body, the Bio-electrode is designed to fit the curvature of SD rat’s head bone. Besides, we use a special connector to transmit signal to back-end system and successfully record Auditory Evoked Potentials (AEP) signal after implant surgery.
Analyzing the ECoG electrode data can preliminarily distinguish the relationship from the main and neighbor auditory response area. Furthermore, high frequency analyzing (Gamma Band) can identify the nerve’s connection and function of brain region. In the future, we will apply our Bio-electrode in Epilepsy detection or Electrical Stimulation, and even combining with Micro-fluidic Channel to execute medicine injection.
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