Effects of In Situ Mechanical Stimuli on the Maturation of Tubular tissue - Implications for Tissue-Engineered Blood Vessels

• Main Authors: Chao-LinChen, 陳照臨
• Other Authors: Jin-Jia Hu
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/96808427316999200261

碩士 === 國立成功大學 === 生物醫學工程學系 === 100 === After decades of efforts, there is still a lack for ideal blood vessel substitute for those internal diameter less than 6mm. Conventional synthetic polymers like PTFE(Polytetrafluoroethylene), PET(Polyethylene teraphthalate) have been popularly applied as medical implantation. But for small blood vessel(〈6mm) applications, their functions are still enormously hampered by foreign body reaction and compliance mismatch. On the other side, tissue-engineered blood vessels are made mainly by culturing cells on biodegradable scaffold and ECM(extra-cellular matrix) in vitro, while bioreactor, a device to simulate physical hemodynamic condition in vitro, has gained its popularity in recent researches with promising results. This study is based on aforementioned footsteps and will look into the effect of mechanical stimulation on biological tissues. We use a custom-made mechanical tester to measure the compliance, burst pressure and suture retention force of tubular tissues, aiming to bring a new hope for small caliber tissue-engineered blood vessels.