| Summary: | 碩士 === 國立中興大學 === 獸醫學系暨研究所 === 100 === The metabolic syndrome is a cluster of risk factors including impaired glucose tolerance, hyperlipidemia and hypertension which are also relevant for the development of Type 2 diabetes and cardiovascular diseases. Cordyceps is a fungus that has been used for various pharmacologic and metabolic purposes. We investigated the effects of Cordyceps sinensis (CS) on blood glucose, cholesterol, and triglyceride in rats. By using rat pancreatic perfusion technique to observe the effects of Cordyceps sinensis on insulin levels. We found that CS could improve the glucose tolerance in oral glucose tolerance test (OGTT), but there was no significant increase in 10 mM glucose-induced insulin secretion. In addition, CS also significantly lowered the cholesterol concentration in blood. These results suggested that Cordycpes sisnensis may had potential beneficial effects on glucose utilization with less insulin secretion. Furthermore, CS may prevent hypercholesterolemia in rats.
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