| Summary: | 碩士 === 國立中興大學 === 食品暨應用生物科技學系所 === 100 === The purpose of this study was to investigate the effects of commercial functional food components on the regulation of intestinal health, blood lipid, anti-inflammatory response, and blood glucose in vivo. The experiment animals were divided into four groups, namely the control, formula A, formula B, and formula C groups. Each treatment group was then subdivided into high dose group and medium dose group.
After feeding the test diets for four weeks, the results showed that there was no significant difference in the viable numbers of fecal total lactic acid bacteria and Clostridium perfringens between the treatment groups and the control. Similarly, no significant difference in fecal pH value, serum triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were found among the four groups, either. However, in respect of fecal moisture content and daily fecal weight, formula B and formula C groups had significantly (p<0.05) higher values than those of formula A and control groups, both at medium and high dosages. On the other hand, formula B and formula C groups were also found to have significantly (p<0.05) lower blood total cholesterol than the other groups, both at medium and high dosages.
For the acute in vivo anti-inflammatory test, mice were fed different formulas at high dose for four weeks, and then injected intraperitoneally with lipopolysaccharide to induce acute inflammation. After statistical analysis, mice in formula B and C groups were found to have lower NO level in serum, when compared to control.
In conclusion, we found that formulas B and C are better intestinal health, serum total cholesterol, and inflammation regulators than formula A. Since formula C is a mixture of formula A and B, we believe formula B should have the best efficacy on improving intestinal function, decreasing blood total cholesterol, and reducing NO level.
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