A Comprehensive Web Server for Human Gene Regulation

• Main Authors: Wei-Hsin Hung, 洪偉欣
• Other Authors: Chun-Chi Liu
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/61676662675720721531

碩士 === 國立中興大學 === 基因體暨生物資訊學研究所 === 100 === Previously, we constructed a composite regulatory signature database (CRSD http://biochip.nchu.edu.tw/crsd1). In this work, based on our previous framework, we established CRSD release 2 (CRSD2, http://syslab.nchu.edu.tw/crsd2). The CRSD2 can predict target genes for microRNAs and transcription factors. Users can use CRSD2 in investigating complex regulatory behaviors involving the microRNA regulatory signatures and TF regulatory signatures. We integrated six large-scale databases to construct two core genome-wide databases. The former are those for microRNAs, promoters, transcription factors, pathways and gene functions, while the latter are microRNA regulatory signatures and transcription factor signatures. In addition, CRSD2 also provides information for single nucleotide polymorphisms.