Investigation of Rhodium-Catalyzed Carbon-Sulfur Bond Cross-Coupling Reaction

• Main Authors: Chih-Shin Lai, 賴志昕
• Other Authors: Chin-Fa Lee
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/92896885392631076933

碩士 === 國立中興大學 === 化學系所 === 100 === Aryl- and alkenyl thioethers are present in many biologically active molecules. As a consequence, many approaches have been described for the synthesis of these compounds. Among these methods, the transition-metal-catalyzed cross-coupling reaction of thiols with aryl halides provides an attractive choice for this purpose due to its mild reaction conditions when compared to traditional methods. In the first part of this thesis, the rhodium-catalyzed cross-coupling reaction of thiols with aryl iodides in the presence of PPh3 as a ligand is described. The preparation of alkenyl thioethers based on rhodium catalyst is also introduced. Interestingly, the chemical yields for alkenyl thioethers can be improved when the catalyst was stirred for a while before addition of thiols and vinyl halides.