Study on the Hydrophilic Coating Materials and Their Film-making Used for Tablets

• Main Author: 賴祥熙
• Other Authors: 吳海萍
• Format: Others
• Language: zh-TW
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/61101526980237473051

碩士 === 明新科技大學 === 化學工程與材料科技研究所 === 100 === Abstract The coatings for the appearance of food and drug products can be categorized into capsule, tablet sugar coating and tablet film coating. The tablet film coating can improve the appearance of tablet, cover the stinging flavors and tastes of tablet ingredients, and prevent the penetration of water as well as moisture into tablet. Nowadays good food- or pharmaceutical-grade polymeric materials are developed for the thin film coating onto the surfaces of tablets. The materials used for this study are hydrophilic polymeric materials Hydroxypropyl Methylcellulose (HPMC) 2910 of 15 cps and 5 cps doped with plasticizer Polyethylene Glycol (PEG) 8000 and 6000, and water as the solvent for the film making process. The characteristic functional groups of HPMC materials and PEG plasticizers were identified by Fourier Transform Infrared Spectroscopy (FT-IR). Differential Scanning Calorimetry (DSC) thermal analysis was performed on PEG 8000 and 6000. The films were made in the stability environmental chamber with a controlled temperature of 25 ℃ and humidity of 50 %. After storing in room temperature for one day, the films were studied by using Thermo-gravimetric Analyzer (TGA), Water Vapor Permeability (WVP) apparatus, and Testometric MIRO 350 for studying the relevant properties of the films made with the above-mentioned materials before as well as after doping. Thermo-gravimetric analysis indicates the loss on drying (LOD) remains 5 % to 6 % for all the films, while the greatest thermo-gravimetric loss occurs at 75-85 ℃ and the heat decomposition starts around 200 ℃.WVP results are from the lowest 11.32 g/m2day for the film made by HPMC 2910 5 cps with 2910 15-5 cps, and highest 19.98 g/m2day for the film made by HPMC 2910 15 cps doped with PEG 8000. These results do not mean a significant WVP difference. Testometric tests show that the film made with HPMC 2910 15 cps have the highest stress break value of 4.8 kg/mm2 and Young’s modulus value of 159.54 kg/mm2. The strain break is increased a lot from 18.339 % to 29.224 % for the film made by doping PEG 6000 into HPMC 2910 15 cps. The energy break and elongation break are also increased, even the stress break and Young’s modulus are decreased somewhat. Therefore this film is considered as the best among all the films made in this study. Keywords：HPMC 2910 15 cps，HPMC 2910 5 cps，PEG 8000，PEG 6000，FT/IR，DSC，TGA，Testometric testing