| Summary: | 碩士 === 高雄醫學大學 === 職業安全衛生研究所 === 100 === The outbreak of melamine-tainted formula milk has raised concern on melamine toxicity of adverse renal outcomes in children. Melamine in the human body''s metabolic pathways and mechanisms remain to be elusive. Recently, our study found that melamine migration can be detectable from daily-use melamine-made tableware, particularly in the high temperature.
In this experiment, each healthy subject will be asked to consume one bowl (melamine-made tableware) of hot noodle soup and collected each one spot urine sample before and after the consumption until 12hr later to investigate the temporal changes of urinary melamine level. The results showed that mean urinary melamine concentrations corrected by urinary creatintine sharply increases in the beginning (0.73μg/mmol Creatinine), reaches the highest plateau around 4-6hr(9.37μg/mmol Creatinine), and sharply declines till 12hrs after the consumption(2.54μg/mmol Creatinine).
The second study was designed as a crossover study. The same result that urinary melamine concentration before hot noodle soup consumption was 1.71μg/mmol Creatinine increasing linearly after consumed the hot soup 6 hours later and reaching the highest concentrations as 6.95μg/mmol creatinine, and then plateaued for the remainder of the study (3.67μg/mmol Creatinine after consumed the hot soup 12 hours later urine).
On the other hand, mean urinary melamine concentrations in the same subjects using ceramics-made tableware didn’t change dramatically.
The total melamine excretion in the group of melamine-made tableware was higher than in the group of ceramics-made tableware, which were significantly different (p=0.0005). Recently, there were studies indicated that even low-dose melamine exposure can play an important role in calcium urolithiasis in adults. Since melamine-made tableware is still commonly used in our daily life, how to choice safety tableware is very important.
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