Pharmacokinetics Studies of Bioactive Constituents between Commercial Extract and Traditional Decoction of Chuan–Xiong–Cha–Tiao–San andShin–Yi– Ching–Fey Tang
碩士 === 高雄醫學大學 === 藥學研究所 === 100 === The purpose of this study was to investigations of bioequivalence between of traditional decoction preparation and commercial extract﹐including Chuan Xiong Cha Tiao San (CXCTS) and Shin Yi Ching Fey Tang (SYCFT)﹒We choose the index components are Glycyrrhizin﹐Feru...
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| Format: | Others |
| Language: | zh-TW |
| Published: |
2012
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| Online Access: | http://ndltd.ncl.edu.tw/handle/39415527260812483419 |
| Summary: | 碩士 === 高雄醫學大學 === 藥學研究所 === 100 === The purpose of this study was to investigations of bioequivalence between of traditional decoction preparation and commercial extract﹐including Chuan Xiong Cha Tiao San (CXCTS) and Shin Yi Ching Fey Tang (SYCFT)﹒We choose the index components are Glycyrrhizin﹐Ferulic acid and Baicalin﹒In this study﹐HPLC methods were used for the quantitation of Glycyrrhizin﹐Baicalin and Ferulic acid in the rabbits plasma﹒
In the experimental results showed that the concentrations of the Glycyrrhizin in the CXCTS commercial extract are higher than CXCTS decoction preparation﹒The results indicated that Tmax of the Glycyrrhizin in the SYCFT decoction preparation are shorter than SYCFT commercial extract﹒The results also indicated that Tmax of the Ferulic acid in the CXCTS decoction preparation are shorter than CXCTS commercial extract﹒The concentrations of the baicalin are not different between the commercial extract and the decoction preparation﹒
In conclusion﹐because commercial extract and decoction preparation are different bioequivalence﹐therefore Chinese medicine practitioners in prescribing should be cautiously﹒
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