Synthesis and anticancer evaluation of 4-anilinofuro[2,3-b]quinoline derivatives

• Main Authors: Yu-Wen Chen, 陳郁旻
• Other Authors: Yeh-Long Chen
• Format: Others
• Language: zh-TW
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/83540955128389734811

博士 === 高雄醫學大學 === 醫藥暨應用化學研究所 === 100 === We have reported the preparation and anticancer evaluation of certain 4-anilinofuro-[2,3-b]quinolines. However, drawbacks such as lack of selective cytotoxicity, poor oral bioavailability, and poor water solubility exhibited by these compounds prompted us to search for newer derivatives. Among them, (E)-1-(4-(furo[2,3-b]quinolin-4-ylamino) phenyl)ethanone O-2-aminoethyloxime (17g) is selectively active against the growth of NCI-H460 and is highly water-soluble (63 μg/mL). Its hydrochloride salt, 17g．3 HCl exhibited not only excellent water solubility (1049 μg/mL) but also a high oral bioavailability (57.1%). Compound 17g may cause cancer cell apoptosis through inducing mitotic arrest and mitotic catastrophe mechanism. Xenographic studies indicated the tumor size with 17g．3 HCl treated nude mice was significantly lower than control. Further evaluation in an orthotopic lung cancer model indicated that 17g．3HCl can be absorbed readily through oral administration, distributed to lung tissue, and exhibited significant efficacy in inhibiting the growth of lung cancers.