The Development of Formula and Quality Control Method for Geraniol Beauty Hydrogel Patch

• Main Authors: Shih-Sheng Chang, 張仕昇
• Other Authors: Ce-Shing Sheu
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/13096993379448666121

碩士 === 朝陽科技大學 === 民生化工產業研發碩士專班 === 100 === In recent years, the modern people use a variety of patch has become a habits. And the patch for the long-term large area of contact with skin, skin care, and even appearance and composition of the patch are very particular about. This experiment use geraniol added to the aqueous drug tape, can enhance the cooling effect and increased persistence. Analysis by gas chromatography, column to VA-1, long 300 meter inner diameter of 0.25 mm, film thickness 0.25 μm analytical column, carrier gas is nitrogen. The injection temperature: 240 ℃, FID detection temperature: 240 ℃, split: 50 : 1, flow rate at a linear velocity of 19.14 psi, an injection volume: 1 μL. The oven temperature was programmed from 80 ℃, then 10 ℃/min ramp to 140 ℃ held for 1 min, then 100 ℃/min ramp to 240 ℃ held for 2 min. Total run time was 10 min. In the analytical method validation of geraniol in beauty hydrogel patch, the results of relative standard deviation are between 0.49% and 3.79%; the results of recovery are between 95.88% and 96.58%; the result of linear regression coefficient is 0.9996; the result of limit of detection is 1.46 ppm; the result of limit of quantification is 4.88ppm. In the stability tests, geraniol beauty hydrogel patch was placed in the room temperature condition 25 ℃ and the accelerated condition 40 ℃ for six-month stability test. The appearance of product did not significantly change and the content of geraniol was declined to 92.34 ％ in the room temperature test and declined to 89.15 ％ in the accelerated test at the six month.