Preparation of N-aryl Aziridines

• Main Authors: Hsin-Chi Chao, 趙星智
• Other Authors: Chia-Hsi Yang
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/57550471258830594389

碩士 === 中原大學 === 化學研究所 === 100 === Aziridine, a high-application value compounds, not only widely used in organic synthesis reactions but also in the synthesis of natural products and medicine often have the structure of the aziridine.In recent years,many chemists put into the reserch because of the aziridine with the anti-tumor biological activity. 　　In this paper, we used a series of aryl azide mix in electron- withdrawing alkenes, under high temperature and solvent environment, prepared a series of corresponding phenyl- substituted nitrogen base aziridine. 　　The characteristics of this experiment is that without complicated steps,it can be simple and efficient to synthesis aziridine. In addition, we also try to adjust the reaction conditions, to makes the reaction selectivity better thereby allowing the production yield increase.