| Summary: | 碩士 === 中臺科技大學 === 醫學工程暨材料研究所 === 100 === Recently the development of bio-chip has been contributing on the breakthrough of biomedical engineering. The “Bio-chip” integrated with the techniques of MEMs, biochemical, and biological technology on a cover glass, is coming to notice since it is convenient, rapid, low-consumables, and accuracy for various biological research and clinical diagnosis. Some commercial products have been used for convenient inspections. In this thesis, a feasibility study is performed by employing the technique of two-photon polymerization (TPP) to fabricate 3-D structured specialized protein or antibody in microfluidic channel, which can be used as the detector of bio-chip. The content includes: (1) to fabricate mechanical structured specialized protein or antibody by TPP as a flat, and then utilize optical tweezers to manipulate the objects, such as Staphylococcus aurous and RBCs, to verify their biological function for the application of bio-detector; (2) to improve the sensing result by changing the slope of flat in the micro-channel. The experimental result is expected to contribute a simply fabricated, stable, and easily observed detector for bio-chip applications.
|
|---|
