Obstructive Sleep Apnea Associated with Proteinuria in Late Mid-Aged Male: A Decision Tree Analysis

• Main Authors: Shu-Yun, 張淑雲
• Other Authors: Hua Ting
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/kpruse

碩士 === 中山醫學大學 === 醫學研究所 === 100 === Proteinuria or obstructive sleep apnea (OSA) was associated with cardiovascular events and mortality. To examine whether OSA is a potential predictor of proteinuria, a data-driven analysis was performed to delineate a potential categorical classification algorithm. In this cross-sectional community-based cohort study, demographic data, blood pressures, serum biochemical analyses, proteinuria via single dipstick urinalysis, and overnight polysomnography were measured in 300 males with sedentary work styles. 61 (20.3%) of 300 participants had proteinuria. Logistic regression analysis showed that glycated hemoglobin (HbA1c), duration of arterial-oxygen-saturation <90%, age, and log high-sensitive C-reactive-protein, but not apnea-hypopnea index (AHI), were responsible for a mere 16.7% of the variance of proteinuria’s presence. A decision tree analysis showed that subjects with age >49 years had a higher risk for proteinuria than ≦49, the counterpart. In the age >49 group, subjects with AHI >21 events/hour had a higher risk for proteinuria; whereas in age ≦49 group, subjects with HbA1c >7%, or with HbA1c ≦7 and body mass index (BMI) >27.4 kg/m2 had a higher risk for proteinuria than their counterparts. AHI was the sole determinant responsible for the presence of proteinuria in late mid-aged male sedentary workers, while HbA1c and BMI were in the juniors. By algorithm analysis, this study provides a comprehensive hierarchical model for better understanding the correlates of proteinuria.