| Summary: | 碩士 === 中山醫學大學 === 醫學研究所 === 100 === Background :According to statistics, the blood pressure lowering drugs is the best selling drug in Taiwan. Taiwan ranked top 20 selling drugs in lowering blood pressure drug accounted for five, the five major antihypertensive drug annual sales of more than 6.5 billion yuan, sales approaching three hundred million, people eat more than eighty per day ten thousand blood pressure lowering drugs. Because hypertension is caused by stroke and coronary heart disease is one important reason, the law is very important to take medicine to control blood pressure, coupled with high blood pressure can not cure, must be long-term control medication, the blood pressure lowering drug use in an aging society amazing amount of big!Including calcium channel blockers is the largest amount of high blood pressure medication category, nornasc topped the list for several years, another calcium channel blocker compound adalat OROS use the next best. Dosage form design technology for the film, the use of laser hole sustained release of active ingredients to achieve long-term stable control of blood pressure-release function. Pharmacokinetics should be better than norvasc, but the actual prescription is different.Objective: So I hope the use of evidence-based medicine practices, the use of literature collected to be analyzed to understand the integration of the research results.Methods: Literature search for evidence-based medicine approach to the use of online databases Medline OVID, Pumed other search through the literature of the appraisal, to filter appropriate documentation, then meta-analysis software to analyze the results of that.Results: We included 11 randomized controlled clinical trials into our study, compared the hypertensive effect between these two calcium channel blockers amlodipine and nifedipine, and use the meta-analysis software “RevMan software” to get the survey results. The results shown that regarding to lowering the systolic blood pressure, the forest plot across the broken center line, revealed that lowering the systolic blood pressure had not significant difference between amlodipine and nifedipine. And regarding to lowering the diastolic blood pressure, the forest plot also across the broken center line, revealed that lowering the diastolic blood pressure had not significant difference between amlodipine and nifedipine.Discussion: The results from meta-analysis software, we could find that the decline in systolic or diastolic blood pressure between amlodipine and nifedipine had similar hypertensive effect. It is helpful for clinical prescription proposal. Based on the similar hypertensive effect, we should consider other factors, like the dosage form and patient’s tolerance. It can be applied to clinical treatment decision to chose a suitable calcium channel blockers.
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