Part I: Synthetic study of glucosamine-based chiralligandsPart II: Synthetic study of fluorescent imidazole derivatives with Zn(II) chelating ligand

• Main Authors: Po-Han, 邱柏翰
• Other Authors: 劉冠妙
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/56514778061424868389

碩士 === 中山醫學大學 === 應用化學系碩士班 === 100 === The thesis is composed of two parts. One is the synthetic study of glucosamine based chiral ligands. D-glucosamine was reacted with 2-bromob- enzoyl chloride followed by protection of the hydroxyl groups to get the amide 129, which cyclized under tin chloride (IV) treatment to afford oxazoline 128. Coupling of the benzyl bromide moiety with amine got the desired glucosamine based chiral chelator. The second part of the thesis is the synthetic study of fluorescent imidazole derivatives with Zn(II) chelating ligand.The diphenylamine substituted 9,10-phenanthren- equinone was reacted with benzaldehyde with a Zn(II) recognition moiety, di-(2-picol- y)amine group, to get the fluorescent imidazole compound 158, but the yield is just 7 %. We will devote our effort to improve the yield, study the photophysical properties and sensing ability of this compound in the future.