| Summary: | 碩士 === 中山醫學大學 === 生化暨生物科技研究所 === 100 === Ischemic stroke, known as cerebral vascular obstruction or poor circulation, is mostly acute. Two main causes for ischemic stroke are cerebral thrombosis and cerebral embolism. Earlier treatment can reduce the severity of the stroke.
Diagnosis of stroke not only can be identified through clinical observations but also several clinic examinations such as NIHSS Score, CT scan, or NMRI techniques. However, there is a lack of high specificity blood examination.
Recent research suggests to collect blood serum between 3 to 24 hours after stroke. Through NIHSS analysis, using neuron-associated protein NSE, S-100β, MBP, and Thrombomodulin (TM). NSE, S-100β, and MBP has been confirmed it is relevant to the neuronal damage ischemic stroke. However, findings regard Thrombomodulin are inconclusive.
Tau protein plays an important role in neural disease such as Alzheimer’s disease (AD). The structural change of Tau causes the interwined microtubule; and neural damages and eventually its failure to function.
This the present study, the Thromomodulin protein and Tau protein were analyzed. The findings indicate the stroke patients’ TM concentration are higher than the non-stork patient (p=0.01) but Tau concentration are not significant different (p=0.1).
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