Study the effects of tricyclic antidepressant on monoamine neurotransmitters and metabolite levels in rat striatun

• Main Authors: Nai-chen Yeh, 葉乃楨
• Other Authors: Kuo-sheng Liu
• Format: Others
• Language: zh-TW
• Published: 2012
• Online Access: http://ndltd.ncl.edu.tw/handle/zmnwmc

碩士 === 嘉南藥理科技大學 === 藥物科技研究所 === 100 === Chronic treatment with morphine may induce tolerance and addition. If it is stopped too abruptly or use the lower dose that may cause withdrawal symptoms. The withdrawal symptoms are in association with neurotransmitters (like dopamine and serotonin). Adult SD rat were rendered physical dependence on morphine by escalating daily doses of subcutaneous morphine for 3 days and induced morphine dependence. This study combined microdialysis sampling with high performance liquid chromatography-electrochemical detection (HPLC-ECD) for the determination of the neurotransmitters and metabolites in the rat striatum to study the effect of tricyclic antidepressants on monoamine neurotransmitter and metabolite levels. The effects of imipramine, triflupromazine, nortriptyline, and protripramine on monoamine neurotransmitters and metabolite levels in the rat striatum were similar to morphine. They may have the potency to reduce the morphine withdrawal symptoms due to morphine like effect.