| Summary: | 碩士 === 嘉南藥理科技大學 === 藥學系 === 102 === Dripping pellets can be originated in the chinese traditional herbs. We made the herbs to the powder and be dripped into the cooling liquid and made the immediate-release form pellet. Later, with the advances in medical technology, we wanted pellet not only be used at immediate-release pellet form. For our research, we wanted to make extended-release form pellets enhancing the dissolution of poorly soluble drugs and release but keep preservative still staying in the pellet.
At first, we referred to the past research and let our poorly soluble preservative and drug dissolve in different amount of agar to develop the optimize formulation of pellets and maintain pellets be sphere shape and smooth surface after freeze-drying, and increase the encapsulation efficiency of model drug. The pellet with agar may have influences in physical properties and dissolution of active constituent; for the prescription of pellet, the different methods to prepare agar gel may also have a difference in pellet’s properties. In our research, we found that if we let agar be gelled in refrigerator, the cooling rate could be faster, so it made agar covered methylparaben and agar covered indomethacin have harder quality. Then we could control agar size after homogenizing, and made these pellets have different release in the same time.
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