| Summary: | 碩士 === 國立陽明大學 === 生物醫學影像暨放射科學系暨研究所 === 99 === Curcumin, a Chinese herb, has been shown with anti-inflammatory and anti-cancer effects for several types of cancers in preclinical studies, and even in clinical trials. Glioblastoma is the most common and most aggressive brain tumor with low survival rate, and is very difficult to be cured by neurosurgery or radiotherapy. Furthermore, the probability of recurrence is usually very high for glioblastomas post treatment. In this study, we used lentivirus vectors constructed with trifusion reporter genes (Fluc/GFP/Tk) and transduced into rat F98 glioblastoma cells to establish an orthotopic F98/FGT glioma-bearing rat model. The animals were divided into four groups: control (vehicle), curcumin alone (120 mg/kg/d administered from day 7 post tumor cells inoculation, radiation alone (local irradiation with 6 Gy on day 11), and combination of curcumin and 6 Gy. The therapeutic efficacy was evaluated with noninvasive bioluminescent imaging and the overall survival.
The result shows that curcumin combined with radiotherapy is able to suppress the brain tumor growth and with the best overall survival as compared with those of the control and mono-treated groups. These results suggest that curcumin may enhance the radiosensitivity of brain tumors to radiotherapy, and may have the potential to be applied for the treatment of glioblastoma in clinic.
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