Revealing Biomodules Availability/Fluctuations and Metastasis-related Proteins by Integrative Omics Analyses

• Main Authors: Lichieh Julie Chu, 朱俐潔
• Other Authors: Wailap Victor Ng
• Format: Others
• Language: en_US
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/27464226146353720328

博士 === 國立陽明大學 === 醫學生物技術暨檢驗學系暨研究所 === 99 === Tandem mass spectrometry is a robust technology for identifying proteins in complex mixtures. Interpretation of the high throughput data is a crucial point for -omics studies. In this study, we established systems analysis platforms for high throughput proteomic data. In Haloarcula marismortui model, we revealed biochemical capabilities and metabolic stress induced systems fluctuations by using an integrative proteomics and network analysis approach; in lung cancer model, we systemic analyzed and compared the identified proteins and their expression patterns between metastatic and non- metastatic secretory proteomes for metastasis-related protein discovery. Here we demonstrated the applications of proteomics and systems biology in basic and cancer researches.