| Summary: | 碩士 === 國立陽明大學 === 口腔生物研究所 === 99 === It is been reported that using the Nb element to replace the V element in Ti6Al4V alloy can reduce the potentially biological side effect ascribed to the V element. Furthermore, the addition of Nb and Zr elements in Ti alloy may reduce the alloy’s elastic modulus (i.e. reduce the stress shielding effect), but still keep the alloy’s good mechanical and biological properties. This study was to produce a nanoscaled surface porosity on the newly developed Ti6Al7Nb (with good mechanical property) and Ti25Nb25Zr (with lower elastic modulus) alloys through using electrochemical anodization treatment. The corrosion resistance and biocompatibility of Ti6Al7Nb and Ti25Nb25Zr alloys, with and without anodization treatment, were investigated. Results showed that comparing to the polished Ti6Al7Nb and Ti25Nb25Zr alloys, the presence of nanoporosity surface layer on the anodized Ti6Al7Nb and Ti25Nb25Zr alloys increased the corrosion resistance (i.e. decreased the corrosion rate and anodic current) in neural simulated blood plasma. This surface nanoporosity layer on Ti6Al7Nb and Ti25Nb25Zr alloys also enhanced the proteins adsorption and human bone marrow mesenchymal stem cells adhesion, proliferation, migration and differentiation.
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