In-vitro study of calcium sulfate hemihydrated and titanium dioxides composites

• Main Authors: Ching-Chiou Chang, 張景邱
• Other Authors: 薛文景
• Format: Others
• Language: zh-TW
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/gk6bex

碩士 === 國立臺北科技大學 === 材料科學與工程研究所 === 99 === Calcium sulfate and titanium dioxides are two kinds of bio-ceramics, because of that both two materials have excellent biocompatibility, non-toxic to human bodies, and also, calcium sulfate is a major component of the skeleton, has been extensively studied and used in orthopedics and dental surgery such as bone defect repair materials. Titanium dioxides have well biocompatibility, therefore can make the surface of materials tightly attach with cells; however, Titanium dioxides has poor mechanicalness after hydrated, so it has to compound with another material to improve the problem. In this experiment, we choose calcium sulfate to be the component, since it is one of the bones’ nutrients, good for bones’ induction, and most of all, have perfect mechanical Properties. Yet it is too fast to be absorbed as embedding into human bodies. This defect might make the filled up bones deficient, and could become a disadvantage factor as tissues growing. For this reason as we stated, we put these two components together to improve the problems exist when one of them are alone. This study makes calcium sulfate and titanium dioxides of composite materials and mix with different percentages by weight, then investigated their physical properties, mechanical Properties, SEM, EDS, XRD, degradation rate, Kinetics of Reaction and biocompatibility. The results we found from this study is that titanium dioxides 10~20 wt% can improve the mechanical properties, and the degeneration rate of titanium dioxides component is slower than pure calcium sulfate. Besides, the chips added with titanium dioxides have much better biocompatibility than pure calcium sulfate. So in this study, we concluded that we can improve the shortcomings when compounding the two materials - calcium sulfate and titanium dioxides - than each of them exists alone.