Quantitative Analysis of Liver Lipid Using Proton Echo Planar Spectroscopic Imaging (PEPSI)

• Main Authors: Shing-Ru Chen, 陳星儒
• Other Authors: Yi-Ru Lin
• Format: Others
• Language: en_US
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/h6qr4d

碩士 === 國立臺灣科技大學 === 醫學工程研究所 === 99 === The study aims to investigate the feasibility and sensitivity of using MR spectroscopic imaging (MRSI) to observe the hepatic steatosis in normal subjects and in subjects with non-alcoholic fatty liver diseases (NAFLD). To our understanding, measuring hepatic steatosis using MRSI techniques has never been reported before. Measuring hepatic steatosis using MRSI techniques will combine all the advantages of MRI and MRS techniques. The measurement will be noninvasive, without radiation hazard. Most important of all, it can provide precise quantification with regional distribution information. The long scan time of MRSI will be shortened by our fast acquisition sequence, proton echo-planar spectroscopic imaging (PEPSI). Since it can be applied to normal subject studies, hepatic MRSI will become a powerful tool for diagnosis of liver diseases. To achieve this goal, we need to investigate post-processing procedure, and quantification method. From the result of investigation, we develop a reasonable time to breath-hold and scan for clinical applications, and can quickly and successfully detect liver lipid contents.