| Summary: | 碩士 === 國立臺灣大學 === 藥學研究所 === 99 === Phytochemical investigation of Schisandra sphenanthera (Schisandraceae) from dichloromethane partition of the acetone extracts led to the isolation of four new sesquiterpenes called schisansphenins A, B, C and D (1, 2, 3, 4) and eleven known compounds such as macelignan (5), 1-(3,4-dimethoxyphenyl)-4-(3,4-methylenedioxyphenyl)-2,3-dimethylbutane (6), chicanine (7), meso-dimethyl dihydroguaraeitic acid (8), schisantherin D (9), 6-O-benzoylgomisin O (10), erythro-austrobailignan-6 (11), gomisin B (12), schisantherin A (13), gomisin G (14) and gomisin C (15).
Structural elucidations for the found compounds were based on spectroscopic analyses such as 1H- and 13C-NMR, including 2D NMR (1H-1H COSY, HMQC, HMBC and NOESY) experiments, and by comparison of their spectroscopic data with those of related metabolites.
The isolated compounds had been tested by dipeptidyl peptidase-4 (DPP-4) inhibition assay. Except erythro-austrobailignan-6 (11), the rest isolated compounds did not show any significant inhibition.
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