| Summary: | 碩士 === 國立臺灣大學 === 化學研究所 === 99 === Multifunctional uniform nanoparticles (NPs) composed of a hollow manganese nanocrystal core and a mesoporous silica shell (H-MnO@mSiO2) functionalized by phosphorescent iridium complex (Ir), and polyethylene glycol (PEG) or folic acid (FA) on the outermost surface have been strategically designed and synthesized. Both H-MnO@mSiO2(Ir)@PEG and H-MnO@mSiO2-FA NPs demonstrates its versatility in various applications. (1) The magnetic core provides the capability for T1 magnetic resonance (MR) imaging. (2) The iridium complex incorporated silica framework serves as both photosensitizer and luminescent chromophore. (3)The nano-channels in the mesoporous silica shell increase the free diffusion of oxygen and water permeability, enhancing photodynamic therapy (PDT) and T1 signal, respectively. Furthermore, for H-MnO@mSiO2(Ir)@PEG NPs, a biocompatible polymer (PEG), is anchored on outermost surface to maintain the pore structure, avoid protein adsorption and then bypasses the RES system in in vivo applications. On the other hand, H-MnO@mSiO2-FA NPs, is able to target at specific cells for bimodal imaging (both MR and optical) and PDT, and minimize collateral damage of non-targeted cells attributed by surface folic acid.
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