Drug delivery study of mesoporous bioglasses (MBGs) via environment triggered release

• Main Authors: Chain-Hua Din, 丁芊華
• Other Authors: Hsiu-Mei Lin
• Format: Others
• Language: zh-TW
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/79541880406543120767

碩士 === 國立臺灣海洋大學 === 生物科技研究所 === 99 === In this study, we used a pH controlled release-responsive system consisting of mesoporous bioglasses (MBGs) based material functionalized on to pore outlets with polyamines capable of interacting with borate ion or boronic acid functionalized gold nanoparticles (B-AuNPs) acting as a caps. The open and close mechanism involves the reversible reaction between polyamines and boronic acids to form boronate esters. Borate ion or B-AuNPs thus act as a suitable cap via the reversible formation of the corresponding boroester bonds with polyamines anchored on the external surface of the mesoporous silica-based solid. This pH controlled release-responsive system operates in aqueous solution and can be triggered by stimuli such as pH changes. This pH controlled release-responsive release can be open in an acidic pH, whereas the system remains closed at neutral pH. On the other hand, we used three model drugs (Safranin O, acetaminophen and neomycin) to investigate the effect of drug-loading and release properties. When the size of drug was too small, such as acetaminophen, to drug release from bond of boronate esters, but choosing suitable size of drug, this pH controlled release-responsive release will have well controlled release effect.