| Summary: | 碩士 === 國立臺灣海洋大學 === 生物科技研究所 === 99 === Research in intelligent drug delivery system is considerably interesting in biomedical fields. The system can be specifically stimulated to perform controlled drug release. In this study, mesoporous bioactive glass (MBG) act as an intelligent drug delivery carrier, modification of the pore outlets of the carrier with photo sensitive coumarin derivative may possess a gate-like block which can be stimulated by different wavelength of UV light to form open and close system. Exposure under UV light > 310 nm wavelength may form cyclobutane dimers through the coumarin derivative and trapping the guest molecules inside the pores. While irradiating the dimerized coumarin modified MBG with shorter wavelength UV light (~ 250 nm) will photo-cleavage the dimmers and regenerate coumarin monomer derivative, letting the guest molecules to release.
In addition, doping rare earth element, europium, into the MBG structure allowed the MBG have the ability of photoluminescence, and its emission intensity will change with the cumulative released amount of the guest molecules in the carrier. Therefore, the extent of guest molecule release can be easily tracked and monitored by the change of luminescence. Herein, we use a model amino acid L-tryptophan as the guest molecule to test the modified MBG to present as an intelligent multi-controlled drug delivery system. Apart from the photoluminescent ability, lanthanides also have the characteristic of imitating calcium ion, which can replace some part of calcium ions in bone and activated the osteoblasts to promote bone formation and inhibit bone degradation and absorption. This calcium imitating capability makes lanthanide a potential treatment for bone diseases, and also makes the carrier a better intelligent drug delivery system for the application on bone repair treatments.
The structural, morphological, textural and optical properties are well characterized by X-ray diffraction, transmission electron microscopy, N2 adsorption/desorption, and photoluminescence spectra, respectively. The results reveal that the lanthanide doped MBG exhibits the typical ordered characteristics of mesostructure. The system demonstrates great potential in light-sensitive intelligent drug delivery systems and disease therapy fields.
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