| Summary: | 碩士 === 國立臺南大學 === 生物科技學系碩士班 === 99 === UV will hurt skin and lead to skin hyperpigmentation. The most
important thing in whitening skin is to reduce and suppress the rate of
melanin’s formation so as to diminish its generation. Thus, melanogenic
inhibitors becomes the important goal of the research of whitening.
Natural substances have been chosen as raw materials to reduce the
side effects of chemical compounds on skins. For example, discovered in
recent years, arbutin can also interfere with the formation of melanin. In
addition to these melanogenesis inhibitors, there are many natural plants
for research, such as green tea extract can inhibit the tyrosinase activity.
The purpose of this study is using zebrafish as an experimental
species and selecting natural components that inhibit the melanogenesis.
In this research, zebrafish embryos were treated with natural components
in 9 hpf. After 39 hours, the fish are fixed and then placed in a
microscope to observe and take photographs. Then the images are
processed by using computer software Photoshop and the black spot areas
of the fish body and tail are calculated by using computer software
ImageJ. The result shows that Lithospermum erythrorhizon; Astragalus
membranaceus; Morus alba; Rehmannia glutinosa; Codonopsis pilosula
and Angelica sinensis can effectively reduce the formation of melanin.
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