Cell death and post-translational modification of procaspase-3 induced by Photofrin-mediated Photodynamic treatment in mammalian cells
博士 === 國立清華大學 === 生物資訊與結構生物研究所 === 99 === Photofrin 是光動力療法中用來治療癌症的第一代光敏劑,主要的治療效果可導致癌細胞的死亡。許多研究發現PDT可以導致各種不同型態的細胞死亡,但是其中的機制還不是非常清楚。我們利用A431細胞進行PDT的研究,發現Photofrin不同處理時間,會分布在細胞不同的區域,照光處理後可以造成細胞不同的死亡型態 [Hsieh et al., (2003) J. Cell. Physiol. 194, 363-375]。在本研究中發現,當Photofrin分布在細胞內胞器中時,處理光照後2-8小時會導致細胞核周圍的...
Main Authors: | Hsieh, Ya-Ju, 謝雅如 |
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Other Authors: | Lyu, Ping-Chiang |
Format: | Others |
Language: | en_US |
Published: |
2010
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Online Access: | http://ndltd.ncl.edu.tw/handle/61188758274879022580 |
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