Risk Factors for Latent Tuberculosis Infection among Health Care Workers in a Southern Hospital
碩士 === 國防醫學院 === 公共衛生學研究所 === 99 === Rationale: Health care workers (HCWs) taking care of and dealing with TB patient’s samples, and therefore become are one of the groups at high risk of Mycobacterium tuberculosis infection through occupational exposure. So the screening of HCWs for latent tubercul...
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ndltd-TW-099NDMC00580342015-10-13T19:35:34Z http://ndltd.ncl.edu.tw/handle/39303237245792379395 Risk Factors for Latent Tuberculosis Infection among Health Care Workers in a Southern Hospital 南部某醫院醫護人員潛隱性結核感染之危險因子探討 Hsin-Yi Cheng 鄭心怡 碩士 國防醫學院 公共衛生學研究所 99 Rationale: Health care workers (HCWs) taking care of and dealing with TB patient’s samples, and therefore become are one of the groups at high risk of Mycobacterium tuberculosis infection through occupational exposure. So the screening of HCWs for latent tuberculosis infection (LTBI) is an important infection control measure. The skin test (e.g., TST), and the blood test (e.g., QuantiFERON®-TB Gold in tube, QFT-GIT…) are available for the diagnosis of LTBI. The specificity of the tuberculin skin test (TST) is low due to cross-reactivity of the purified protein derivatives (PPD) with the Bacille Calmette-Guérin (BCG) vaccine and with most nontuberculous mycobacteria (NTM). QFT-GIT is unaffected by previous BCG vaccination and most NTM. Aims: The purpose of this study is to understand the prevalent situation and risk factors for LTBI among HCWs in southern Taiwan using the QFT-GIT. Methods: A cross-sectional study was conducted from August 2010 to March 2011 among HCWs in the southern hospital. This study was approved by the Southern Hospital Ethics Committee. 180 HCWs enrolled were required to provide written informed consent. All participants underwent QFT-GIT and completed a questionnaire containing data on demography, medical history, subjective symptoms, life style, living environment, working conditions, medical work situation that provided information on possible risk factors for LTBI. Statistical analyses were performed using SAS software version 9.2. Results: 47 (26.11%) had a positive QFT-GIT. Living with others (OR=5.50, 95%CI=1.19-25.42), poor ventilation at home (OR=3.82, 95%CI=1.45-10.06), poor ventilation in the office (OR=2.34, 95%CI=1.01-5.44), and coffee consumption (OR=3.35, 95%CI=1.35-8.32) was associated with increased risk of a positive QFT-GIT in multivariate analysis. Conclusions: This study found that one fourth of HCWs had LTBI. Obviously, we should be concerned about the issue of M. tuberculosis infection at health care facilities for HCWs because there are some units with inadequate ventilation systems and infection control regulations, for example the TB unit. Inadequate ventilation at home, living with another person as well as drinking coffee are risk factors for LTBI. Therefore households should have adequate ventilations or have windows open whilst making sure family and roommates do not have TB. HCW who drink coffee should be aware of fatigue or staying up so late, adequate sleep is recommended. Chih-Hung Ku 辜志弘 2011 學位論文 ; thesis 117 zh-TW |
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碩士 === 國防醫學院 === 公共衛生學研究所 === 99 === Rationale: Health care workers (HCWs) taking care of and dealing with TB patient’s samples, and therefore become are one of the groups at high risk of Mycobacterium tuberculosis infection through occupational exposure. So the screening of HCWs for latent tuberculosis infection (LTBI) is an important infection control measure. The skin test (e.g., TST), and the blood test (e.g., QuantiFERON®-TB Gold in tube, QFT-GIT…) are available for the diagnosis of LTBI. The specificity of the tuberculin skin test (TST) is low due to cross-reactivity of the purified protein derivatives (PPD) with the Bacille Calmette-Guérin (BCG) vaccine and with most nontuberculous mycobacteria (NTM). QFT-GIT is unaffected by previous BCG vaccination and most NTM.
Aims: The purpose of this study is to understand the prevalent situation and risk factors for LTBI among HCWs in southern Taiwan using the QFT-GIT.
Methods: A cross-sectional study was conducted from August 2010 to March 2011 among HCWs in the southern hospital. This study was approved by the Southern Hospital Ethics Committee. 180 HCWs enrolled were required to provide written informed consent. All participants underwent QFT-GIT and completed a questionnaire containing data on demography, medical history, subjective symptoms, life style, living environment, working conditions, medical work situation that provided information on possible risk factors for LTBI. Statistical analyses were performed using SAS software version 9.2.
Results: 47 (26.11%) had a positive QFT-GIT. Living with others (OR=5.50, 95%CI=1.19-25.42), poor ventilation at home (OR=3.82, 95%CI=1.45-10.06), poor ventilation in the office (OR=2.34, 95%CI=1.01-5.44), and coffee consumption (OR=3.35, 95%CI=1.35-8.32) was associated with increased risk of a positive QFT-GIT in multivariate analysis.
Conclusions: This study found that one fourth of HCWs had LTBI. Obviously, we should be concerned about the issue of M. tuberculosis infection at health care facilities for HCWs because there are some units with inadequate ventilation systems and infection control regulations, for example the TB unit. Inadequate ventilation at home, living with another person as well as drinking coffee are risk factors for LTBI. Therefore households should have adequate ventilations or have windows open whilst making sure family and roommates do not have TB. HCW who drink coffee should be aware of fatigue or staying up so late, adequate sleep is recommended.
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author2 |
Chih-Hung Ku |
author_facet |
Chih-Hung Ku Hsin-Yi Cheng 鄭心怡 |
author |
Hsin-Yi Cheng 鄭心怡 |
spellingShingle |
Hsin-Yi Cheng 鄭心怡 Risk Factors for Latent Tuberculosis Infection among Health Care Workers in a Southern Hospital |
author_sort |
Hsin-Yi Cheng |
title |
Risk Factors for Latent Tuberculosis Infection among Health Care Workers in a Southern Hospital |
title_short |
Risk Factors for Latent Tuberculosis Infection among Health Care Workers in a Southern Hospital |
title_full |
Risk Factors for Latent Tuberculosis Infection among Health Care Workers in a Southern Hospital |
title_fullStr |
Risk Factors for Latent Tuberculosis Infection among Health Care Workers in a Southern Hospital |
title_full_unstemmed |
Risk Factors for Latent Tuberculosis Infection among Health Care Workers in a Southern Hospital |
title_sort |
risk factors for latent tuberculosis infection among health care workers in a southern hospital |
publishDate |
2011 |
url |
http://ndltd.ncl.edu.tw/handle/39303237245792379395 |
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