The Effects of Biogenic Molecules, Thiol and Antimalarial Drugs on Biocrystallization Kinetics of β-Hematin Formation

• Main Authors: Ming-Han Tsai, 蔡旻翰
• Other Authors: Tu Lee
• Format: Others
• Language: en_US
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/47963795835293522260

碩士 === 國立中央大學 === 化學工程與材料工程研究所 === 99 === About 40% of the world’s population lives in a threat from malaria infection. According to the current statistics, there were more than hundred millions of clinical cases and 800,000 deaths each year. Malaria was caused by Plasmodium parasites, which Plasmodium falciparum was one of the Plasmodium parasites that caused the most death in the world. Although the present antimalarial drugs worked well in treatments, the war against malaria was not over yet. Drug resistance began to develop due to the widely used of antimalarial drugs. Therefore, it is necessary to screen and develop new antimalarial drugs. There were five types of drug targets in malaria treatment, and we focused on interfering the biocrystallization process of hemozoin, also called β-hematin, formation (consists of ferriprotoporphyrin, Fe(III)PPIX). In this work, we not only modified the drug screening method for antimalarials and successfully developed a plausible drug combination to fight against malaria, but also mapped out the reaction mechanism for biocrystallization of hemozoin and discovered the importance of the lipid blends upon an active promoter (1,2-dioleoyl-sn-gylcero-3-phosphocholine) and an inactive promoter (palmitic acid).