Supramolecular Assembly of Polypeptide Secondary Structures Confined in Nanolamellas

• Main Authors: Miao, Chia-Chun, 繆佳君
• Other Authors: 張豐志
• Format: Others
• Language: zh-TW
• Published: 2011
• Online Access: http://ndltd.ncl.edu.tw/handle/96879768088018167256

碩士 === 國立交通大學 === 應用化學系碩博士班 === 99 === U-PBLG (uracil functional group tethered to poly(γ-benzyl-L-glutamate)) and MD-POSS (muti-diamidopyridine functionalized POSS) were synthesized via ring opening polymerization(ROP) and click reaction. The molecular recognition of U-PBLG/MD-POSS results in various morphological changes. The association constant (Ka) for the complex, shows chemical shift of the amide proton of diamidopyridine in the complex U-PBLG/ MD-POSS was 114.07 M–1. The incorporation of MD-POSS into U-PBLG complex forms highly stable hydrogen-bonded complexes led to the red shift in CD spectra. The distance between the plane of hexagonally packed PBLG rods corresponding to d spacing of (31/2)q and 2q appeared in some blends to provide a driving force to form self-assemble into a thermodynamic stable of twisted macromolecular structures. U-PBLG/ MD-POSS blends complex that exhibited ordered cholesteric lamellar structures, with the d spacing being controlled by changing the U-PBLG content.