| Summary: | 博士 === 國立交通大學 === 機械工程學系 === 99 === Electrospinning is a simple and versatile method for fibers preparation, which employs electrostatic forces that strength a polymer jet to generate continuous fibers with diameters ranging from micrometers down to several nanometers. Electrospinning is an interesting technique for spinning PLLA / composites. The process offers an excellent opportunity for designing the surface morphology and porosity of the fibers to provide the most appropriate interface for biomedical application.
Over the past few decades, polymer composites have replaced many of the conventional metals/materials in various applications. This trends may arise from the advantages polymer composites offer over conventional materials. The most important advantages of using polymer composites are the ease of processing, productivity, and cost reduction. In many of these applications, the properties of polymers composites are modified using fillers and fibers to suit the high strength/specific properties requirements. Polymer composites offer advantages over other conventional materials when specific properties are required. These composites are finding applications in diverse fields from electronic appliances to spacecrafts. These research presents some possible applications in the field of biomedical thin films.
The study found that biodegradable drug delivery membranes that were fabricated from Poly(α-L-alanine) (PLLA) and chlorhexidine (CHX)-gluconate via electrospinning could steadily and continuously inhibit the growth of bacteria. Bacterial growth curves were used to evaluate on a real-time basis the relationship between drug delivery speeds of the membranes and growth rates of bacteria in different phases.
Besides, this paper proposes a novel idea, i.e. to produce bio-degradable GTR or GBR membranes with calcium carbonate and its polymorphism, aragonite, through electrospinning. Calcium carbonate enjoys fair bio-compatibility, while its polymorphism has a different lattice structure which means different mechanical properties. We can tell that PLLA with 5% aragonite offered a yield strength than pure PLLA by approximately 35％. There is a potential that adding calcite or aragonite of different percentage can produce membranes with different mechanical strength for wider applications.
This article provides a comprehensive review of the ultraviolet resistance ability, bio-degradation and structural differences of UV absorption and anti-oxidation agents. We use the elements (UV absorption and anti-oxidation agents) composite with PLLA by electrospinning in our study. We observed the PLLA/ UV absorption (Benzophenone-12) fiber membranes higher than PLLA membrane 14.9% in UVA ratio. In this experiment, although both are bio-degradable membranes, the the PLLA/ UV absorption (Benzophenone-12) fiber membranes higher than PLLA membrane 61.6% in I875/I1452 Raman intensity ratio. So PLLA Add UV absorption (Benzophenone-12) fiber membranes can achieve good UV resistance and fast bio-degradation.
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