Synchronization Study of Regional Local Field Potential in Rat after Dopamine Receptor Stimulation

• Main Authors: Liu, Ta-Wei, 劉達偉
• Other Authors: Chen, You-Yin
• Format: Others
• Language: en_US
• Published: 2010
• Online Access: http://ndltd.ncl.edu.tw/handle/43705396281058367763

碩士 === 國立交通大學 === 電控工程研究所 === 99 === Neural oscillation represent the neural activity in nervous system, by recording neural oscillation connectivity and interactions within brain networks could be investigated in an effective measure. A wealth of research have suggested that electrophysiological signals in brain networks would interact with each other, and synchronization between distinct areas has been implied the mechanism for brain interaction. With disease influence or external stimulation, the neural oscillation induce linear and non-linear interaction. However, the neural oscillation interaction originated from different brain areas need more investigation to realize the operation in brain networks. Therefore, the aim of this thesis attempts to explore the non-linear interaction with cross-frequency coupling in brain network during the stimulation of dopamine receptors. We record local field potential (LFP) in rats from striatum and motor cortex, giving stimulation on dopamine D2 receptors with dopamine receptor agonist and antagonist. Analysis with coherence and bispectral analysis discuss LFP synchronization between striatum and motor cortex that changes with drug stimulations, discussing the interaction between brain areas with and without drug stimulations. Results demonstrate that oscillations between striatum and motor cortex at delta and theta bands appear significant inverse synchrony changes in identical frequency band with different stimulations. Meanwhile, different stimulations induce cross-frequency bands synchronized or interferential synchrony fluctuations in brain with direction specificity, providing a further investigation and a special point of view in intracerebral neural oscillations interaction in neural network when dopamine receptors stimulated by drugs.