| Summary: | 碩士 === 國立交通大學 === 照明與能源光電研究所 === 99 === Near-infrared spectroscopy is a novel measuring technology in neuroscience. It can be used to non-invasively measure the relative concentrations of oxy-hemoglobin (HbO2) and deoxy- hemoglobin (HbR) which can reflect the information related to cerebral blood volume and cerebral oxygen saturation. Therefore, it has the potential for noninvasive monitoring of cerebra ischemia. However, it still lacks reliable physiological information in cerebra ischemia. In this study, we attempt to find meaningful information related to cerebra ischemia from the relative concentrations of HbO2 and HbR measured by near-infrared spectroscopy. The value of L/P ratio measured by using microdylasis is also used to compare with the concentration variation of HbR and HbO2 under middle cerebral artery occlusion. The rat brain slices with triphenyltetrazolium chloride stain is made to confirm the infract region of the rat brain caused by middle cerebral artery occlusion. Finally, total haemoglobin concentration and concentration difference between HbO2 and HbR for cerebra ischemia are also investigated. The experimental results show the concentration variation of HbR and HbO2 certainly can reflect the state of cerebra ischemia, and the concentration difference between HbO2 and HbR can provide meaningful information for monitoring cerebra ischemia.
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